Pharmacological Evaluation of Novel 1,3,4-Oxadiazole Derivatives

Aswathy Ramesh; Rakesh Kumar Jat; R  Arunkumar

doi:10.22270/ijmspr.v10i1.88

Authors

Aswathy Ramesh PhD scholar, JJT University, Rajasthan, Jhunjhunu, India
Rakesh Kumar Jat HOD, Department of Pharmacy, JJT University, Rajasthan, Jhunjhunu, India
R Arunkumar Principal, Holygrace Academy of Pharmacy, Thrissur, Kerala, India

DOI:

https://doi.org/10.22270/ijmspr.v10i1.88

Keywords:

1,3,4-oxadiazole, antibacterial activity, anticancer activity, antidiabetic activity

Abstract

A series of 2, 5- disubstituted- 1, 3, 4-oxadiazole derivatives (Ox1-Ox10) are synthesized by the ring condensation reaction followed by rearrangement of salicylic acid and phenyl acetic acid with various aromatic acids in presence of phosphorous oxychloride as cyclizing agent. Structure of the new derivatives are confirmed by spectral analysis. Those derivatives having high Pa value in PASS software are subjected to antibacterial, anticancer and antidiabetic studies which yield promising reports. This study helps and stimulate the researcher to exploit the oxadiazole nuclei for the development of more active less harmful drugs.

Keywords: 1,3,4-oxadiazole, antibacterial activity, anticancer activity, antidiabetic activity

Author Biographies

Aswathy Ramesh, PhD scholar, JJT University, Rajasthan, Jhunjhunu, India

PhD scholar, JJT University, Rajasthan, Jhunjhunu, India

Rakesh Kumar Jat, HOD, Department of Pharmacy, JJT University, Rajasthan, Jhunjhunu, India

HOD, Department of Pharmacy, JJT University, Rajasthan, Jhunjhunu, India

R Arunkumar, Principal, Holygrace Academy of Pharmacy, Thrissur, Kerala, India

Principal, Holygrace Academy of Pharmacy, Thrissur, Kerala, India

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