An Investigation of Antipsychotic Activity of Plant Extracts in Experimental Animals

K K  Chitra; Rakesh Kumar Jat

doi:10.22270/ijmspr.v10i4.128

Authors

K K Chitra Research Scholar, Institute of Pharmacy, S.J.J.T. University, Chudela, Jhunjhunu, Rajisthan, India
Rakesh Kumar Jat Professor & Principal, Institute of Pharmacy, S.J.J.T. University, Chudela, Jhunjhunu, Rajisthan, India

DOI:

https://doi.org/10.22270/ijmspr.v10i4.128

Keywords:

Ipomoea reniformis, apomorphine, locust bean gum, pilocarpine, hallucinations, antipychotic activity

Abstract

The current study is done on plant extracts as antipsychotic medication in ayurvedic formulation. The hallucinations are induced by electro shock therapy or apomorphine. After induction of hallucinations the plant extract is administered as standard group, control group and simple group of six albino rats and the results are screened and analyzed with standard drug comparision. Pre-treatment of MEIR (methanolic extract of Ipomoea reniformis) for 15days at the dose of 200 and 400 milligram per kilogram body weight was used to evaluate antipsychotic activity. The antipsychotic activity was also studied against Apomorphine induced stereotype behavior in rats, Pilocarpine induced purposeless chewing in rats and Apomorphine induced climbing behavior in mice. In pre-treatment studies of antipsychotic activity, MEIR at the dose of 200 and 400 milligram per kilogram body weight significantly (p<0.001) reduced the stereotyped behavior against Apomorphine induced stereotypy behavior model. In Pilocarpine induced purposeless chewing behavior, MEIR at the dose of 200 and 400 milligram per kilogram body weight significantly (p<0.01) decreased chewing behavior and in Apomorphine induced climbing behavior, MEIR significantly (p<0.001) reduced the climbing activity at the dose of 200 and 400 milligram per kilogram body weight. The results of the Pr (+) study suggest that the MEIR possess antipsychotic activity in rats and mice. The results of each activites are compared with standard medicament and evaluated.

Keywords: Ipomoea reniformis, apomorphine, locust bean gum, pilocarpine, hallucinations, antipychotic activity

Author Biographies

K K Chitra , Research Scholar, Institute of Pharmacy, S.J.J.T. University, Chudela, Jhunjhunu, Rajisthan, India

Research Scholar, Institute of Pharmacy, S.J.J.T. University, Chudela, Jhunjhunu, Rajisthan, India

Rakesh Kumar Jat, Professor & Principal, Institute of Pharmacy, S.J.J.T. University, Chudela, Jhunjhunu, Rajisthan, India

Professor & Principal, Institute of Pharmacy, S.J.J.T. University, Chudela, Jhunjhunu, Rajisthan, India

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