Anemia in Pregnancy: The Role of Iron Transport and Regulation
DOI:
https://doi.org/10.22270/ijmspr.v11i1.136Keywords:
anemia, pregnancy, iron transport, iron regulation, maternal healthAbstract
Anemia in pregnancy is a common and significant condition that can adversely affect both maternal and fetal health. Among the various types of anemia, iron deficiency anemia (IDA) is the most prevalent and is primarily caused by insufficient iron intake, impaired absorption, or increased iron demand during pregnancy. Iron plays a crucial role in hemoglobin production, and its transport and regulation are key factors in maintaining adequate iron levels for oxygen delivery. This review explores the mechanisms of iron transport and regulation in pregnancy and their implications for anemia. Understanding these biological processes is essential for improving the diagnosis, treatment, and prevention of iron deficiency anemia during pregnancy. The regulation of iron homeostasis involves a complex network of proteins and hormones that control iron absorption, transport, and storage. Hepcidin, a hormone produced by the liver, is the primary regulator of iron metabolism, modulating the absorption of iron from the gastrointestinal tract and its release from storage sites. During pregnancy, the body adapts to meet the increased iron demand by enhancing iron absorption and mobilizing iron stores. However, disruptions in iron regulation, such as increased hepcidin levels due to inflammation or inadequate dietary intake, can lead to functional iron deficiency, even in the presence of normal iron stores. The review discusses these regulatory mechanisms and their impact on iron deficiency anemia in pregnancy.
Keywords: anemia, pregnancy, iron transport, iron regulation, maternal health
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