Diabetes Mellitus: A Review
DOI:
https://doi.org/10.22270/ijmspr.v10i2.97Keywords:
polyuria, polydipsia, polyphagia, ketoacidosis, strokeAbstract
Diabetes mellitus (DM), or diabetes, is a collection of metabolic illnesses wherein someone has excessive blood sugar, since the body no longer produces sufficient insulin or because cells no longer reply to the insulin it produces. This excessive blood sugar produces the classical signs of polyuria (common urination), polydipsia (expanded thirst), and polyphagia (expanded hunger). There are three types, mainly: Type 1 DM results from the body's failure to provide sufficient insulin. This shape was formerly noted as “insulin-based diabetes mellitus or juvenile diabetes.”. The case is unknown. Type 2 DM starts with insulin resistance, a situation wherein cells fail to respond to insulin properly. This shape was formerly mentioned as “noninsulin-structured diabetes mellitus” or “adult-onset diabetics.” The number one reason is immoderate frame weight and no longer sufficient exercise. Gestational diabetes is the third main form that occurs when pregnant women without a previous history of diabetes develop a high blood glucose level. Prevention and treatment involve a healthy diet, physical exercise, not using tobacco, and having a normal body weight. Type 1 diabetics ought to be controlled with insulin injections. Type 2 diabetics may be treated with medications with or without insulin. Insulin and some oral medications can cause reduced BP and the proper weight to be maintained. Gestational diabetics usually resolve after the birth of the body.
Keywords: polyuria, polydipsia, polyphagia, ketoacidosis, stroke.
References
Ribeiro C, de Alencar Mota CS, Voltarelli FA, de Araújo MB, Botezelli JD, et al. Effects of Moderate Intensity Physical Training in Neonatal Alloxan Administered Rats. J. Diabetes Metab. 2010; 1:107. https://doi.org/10.4172/2155-6156.1000107
https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002194/
Ozougwu J.C, Obimba K.C, Belonwu C.D and Unakalamba C.B, "The pathogenesis and pathophysiology of type 1 and type 2 diabetes mellitus", Journal of Physiology and Pathophysiology 2013; 4(4):46-57. https://doi.org/10.5897/JPAP2013.0001
Clark A, Jones LC, de Koning E, Hansen BC, Matthews DR, Diabetes, 2001.
Lemos Costa TMR, Detsch JM, Pimazoni-Netto A, de Almeida ACR, Sztal- Mazer S, et al. Glycemic Variability and Mean Weekly Glucose in the Evaluation and Treatment of Blood Glucose in Gestational Diabetes Mellitus; Evidence for Lower Neonatal Complications. J. Diabetes Metab. 2011; 2:137. https://doi.org/10.4172/2155-6156.1000137
Ragheb R, Medhat AM. Mechanisms of Fatty Acid-Induced Insulin Resistance in Muscle and Liver. J. Diabetes Metab. 2011; 2:127. https://doi.org/10.4172/2155-6156.1000127
Mungrue K, Roper LA, Chung T. Assessment of Weight Loss in theManagement of Patients with Type 2 Diabetes Mellitus in Primary Care in Trinidad. J. Diabetes Metab. 2011; 2:120.447389646377 https://doi.org/10.4172/2155-6156.1000120
Alina S, Barbara R, Krzysztof G, Barbara G, Mare k G, et al. Elevation of sE-Selectin Levels from 2-24 Months Following Gestational Diabetesis Associated with Early Cardiometabolic Risk in Non-Diabetic Women. J. Diabetes Metab. 2011; 2:138. https://doi.org/10.4172/2155-6156.1000138
Kablan A, Saunders RA, Szkudlarek-Mikho M, Chin JB, Bosio RM, et al. Prieurianin Causes Weight Loss in Diet-Induced Obese Mice and Inhibits Adipogenesis in Cultured Preadipocytes. J. Diabetes Metab. 2010; 1:101. https://doi.org/10.4172/2155-6156.1000101
PMid:21572918 PMCid:PMC3093537
Taloyan M, Saleh-Stattin N, Johansson SE, Agréus L, Wändell P. Differences in Cardiovascular Risk Factors in Swedes and Assyrians/Syrians with Type 2 Diabetes: Association with Lifestyle-Related Factors. J. Diabetes Metab. 2010; 1:110. https://doi.org/10.4172/2155-6156.1000110
MungrueK, Roper LA, Chung T. Assessment of Weight Loss in the Management of Patients with Type 2 Diabetes Mellitus in Primary Care in Trinidad. J. Diabetes Metab. 2011; 2:120. https://doi.org/10.4172/2155-6156.1000120
Recent trends in therapeutic approaches for diabetes management: a comprehensive update. International Diabetes Federation. IDF Diabetes Atlas. 6th ed. International Diabetes Federation. Brussels, Belgium; 2013.
Wassmuth R, Lernmark A International Diabetes Federation. IDF. The genetics of susceptibility to diabetes, CLIN Immunol, Immunopathol. 1989; 53:358-399. https://doi.org/10.1016/0090-1229(89)90002-0 PMid:2680191
Guariguata L, Whiting DR, Hambleton I, et al. Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes research and clinical practice. 2014;103(2):137-149. https://doi.org/10.1016/j.diabres.2013.11.002 PMid:24630390
World Health Organization. Global report on diabetes. Geneva; 2016.
Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes research and clinical practice. 2010;87(1):4-14. https://doi.org/10.1016/j.diabres.2009.10.007 PMid:19896746
Williams R. Diabetes in the UK--How big is the problem? Journal of Dentistry. 2009;37(8):S573-S4 https://doi.org/10.1016/j.jdent.2009.05.014 PMid:19487062
Gonzalez EL, Johansson S, Wallander MA, et al. Trends in the prevalence and incidence of diabetes in the UK: 1996-2005. J Epidemiol Community Health. 2009;63(4):332-336. https://doi.org/10.1136/jech.2008.080382 PMid:19240084
Wild S, Roglic G, Green A, et al. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27(5):1047-1053. https://doi.org/10.2337/diacare.27.5.1047 PMid:15111519
Joshi SK, Shrestha S. Diabetes mellitus: a review of its associations with different environmental factors. Kathmandu Univ Med J (KUMJ). 2010;8(29):109-115. https://doi.org/10.3126/kumj.v8i1.3233 PMid:21209519
Bardsley, Joan K, Want, et al. Overview of diabetes. Critical Care Nursing Quarterly. 2004;27(2):106-112. https://doi.org/10.1097/00002727-200404000-00002 PMid:15137353
Currie CJ, Peters JR, Evans M. Dispensing patterns and financial costs of glucose-lowering therapies in the UK from 2000 to 2008. Diabetic medicine : a journal of the BritishDiabeticAssociation.2010;27(7):744-752. https://doi.org/10.1111/j.1464-5491.2009.02849.x PMid:20636954
Bagust A, Hopkinson PK, Maslove L, et al. The projected health care burden of Type 2 diabetes in the UK from 2000 to 2060. Diabetic Medicine. 2002;19:1-5. https://doi.org/10.1046/j.1464-5491.19.s4.2.x PMid:12121330
Sheldon TA, Cullum N, Dawson D, et al. What's the evidence that NICE guidance has been implemented? Results from a national evaluation using time series analysis, audit of patients' notes, and interviews. Bmj. 2004;329(7473):999. https://doi.org/10.1136/bmj.329.7473.999
PMid:15514342 PMCid:PMC524545
Lee SJ, Boscardin WJ, Stijacic Cenzer I, et al. The risks and benefits of implementing glycemic control guidelines in frail older adults with diabetes mellitus. J Am Geriatr Soc. 2011;59(4):666-672. https://doi.org/10.1111/j.1532-5415.2011.03362.x PMid:21480838 PMCid:PMC3764989
NHS Diabetes. NICE and Diabetes: A Summary of Relevant Guidelines. 2009.
Choe HM, Bernstein SJ, Cooke D, et al. Using a multidisciplinary team and clinical redesign to improve blood pressure control in patients with diabetes. Qual Manag Health Care. 2008;17(3):227-233. https://doi.org/10.1097/01.QMH.0000326727.01203.99
PMid:18641505
Ciofeta, M., Lalli, C., Del, S. P. Contribution of postprandial versus interprandial blood glucose to HbA1c in type I diabetes on physiologic intensive therapy with lispro insulin at mealtime. Diabetes Care. 1999;22:795-800. https://doi.org/10.2337/diacare.22.5.795 PMid:10332684
Henry, R.R., Gumbiner, B.N., Ditzler, T. Intensive conventional insulin therapy for type II Diabetes. Metabolic effects during 6 month outpatient trial. Diabetes Care, 16: 21-31 (1993). https://doi.org/10.2337/diacare.16.1.21 PMid:8422777
Diabetes Control and Complications Trial Research Group. The effects of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Eng J Med., 1993;329:977-986. https://doi.org/10.1056/NEJM199309303291401 PMid:8366922
Dhakar RC, Maurya SD, Aggarwal S, Kumar G, Tilak VK , Design and evaluation of SRM microspheres of metformin hydrochloride, Pharmacie Globale (IJCP). 2010;1(07).
Bailey, C.J. Biguanides and NIDDM. Diabetes Care 1992;15:755-772. https://doi.org/10.2337/diacare.15.6.755 PMid:1600835
Clarke, B.F., and Duncan, L.J.P. Biguanide treatment in the management of insulin-dependent (maturity-onset) diabetes: clinical experience with metformin. Res. Clin. Forums 1979L1:53-63.
Hundal, H.S., Ramlal, T., Reyes, R. The cellular mechanism of metformin action involves glucose transporter translocation from an intracellular pool to the plasma membrane in L6 muscle cells. Endocrinology 1992;131:1165-1173. https://doi.org/10.1210/endo.131.3.1505458 PMid:1505458
Rahman, A.R., Zaman, K. Medicinal Plants with Hypoglycemic Activity. J Ethon Pharmocol 1989;26:1-55. https://doi.org/10.1016/0378-8741(89)90112-8 PMid:2664356
Modak, M., Dixit, P., Londhe, J. Devasagayam. Indian herbs and herbal drugs used for the treatment of diabetes. J Clin BioChem Nutri 007;40:163-73. https://doi.org/10.3164/jcbn.40.163 PMid:18398493 PMCid:PMC2275761
Meena R, Prajapati SK, Nagar R, Porwal O, Nagar T, Tilak VK, Jayakumararaj R, Arya RKK, Dhakar RC, Application of Moringa oleifera in Dentistry, Asian Journal of Dental and Health Sciences, 2021;1(1):10-13 https://doi.org/10.22270/ajdhs.v1i1.5
International Expert Committee. International Expert Committee report on the role of the A1C assay in the diagnosis of diabetes. Diabetes Care. 2009; 32:1327-1334. https://doi.org/10.2337/dc09-9033 PMid:19502545 PMCid:PMC2699715
American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2009;32 Suppl 1:S62-S67. https://doi.org/10.2337/dc09-S062 PMid:19118289 PMCid:PMC2613584
World Health Organization. Use of glycated hemoglobin (HbA1c) in the diagnosis of diabetes mellitus: Abbreviated report of a WHO consultant. Available from: https://www.who.int/diabetes/publications/report-hba1c_2011.pdf.
Sacks DB, Arnold M, Bakris GL, Bruns DE, Horvath AR, Kirkman MS, Lernmark A, Metzger BE, Nathan DM. Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus. Clin Chem. 2011;57: e1-e47. https://doi.org/10.1373/clinchem.2010.161596 PMid:21617152
McDonald TJ, Warren R. Diagnostic confusion? Repeat HbA1c for the diagnosis of diabetes. Diabetes Care. 2014;37: e135-e136. https://doi.org/10.2337/dc14-0055 PMid:24855169
Ross and Wilson. Anatomy and Pathophysiology in Health and Illness, Churchill Livingstone Elsevier, 11th edition, 2010, 227-229.
Gupta OP, Joshi MH, Daves SK. Prevalence of Diabetes in India, Adv Metab Disord. 1978; 9:147-65. https://doi.org/10.1016/B978-0-12-027309-6.50013-6 PMid:645491
Ross and Wilson. Anatomy and Pathophysiology in Health and Illness, Churchill Livingstone Elsevier, 11th edition, 2010, 227-22.
Varghese RT, Salini R, Abraham P, Reshma KK, Vijayakumar K. Determinants of the quality of life among diabetic subjects in Kerala, India. Diabetes & Metab Syndrome: Clin Res Rev. 2007; 1:173-9. [Google Scholar]VD, Meroz P, Ramadevi Ch, Mahesh T. Health related quality of life (HRQoL). https://doi.org/10.1016/j.dsx.2007.05.005
Sasi Sekhar T in Gestational Diabetes Mellitus: A cross-sectional study in tertiary healthcare Centre. Int J Sci Res. 2018; 7:24-6.
Kumar N, Singh Y, Singh S, Rana V. Quality of life of type 1 diabetic Indian children and adolescents-Cross sectional study. Int J Health Sci Res. 2020; 10:1-9.
Published
How to Cite
Issue
Section
Copyright (c) 2024 Tadikonda Rama Rao, Gayatri Nagakameshwari Tejomurtula

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

.