Novel Bioactive Compounds from Marine Sources as a Tool for Drug Development

Authors

  • Geeta Sahu Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001
  • Geeta Kachhi Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001
  • Bhupendra Thakur Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001
  • Anushree Jain Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001
  • Prateek Kumar Jain Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001
  • Basant Khare Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

DOI:

https://doi.org/10.22270/ijmspr.v8i3.57

Keywords:

Anticancer, Bryostatin, Cytarabine, Keyhole limpet hemocyanin, Mariculture, Sponge, Ziconotide

Abstract

The marine environment is a relatively unexplored source of functional ingredients that can be used in food processing, storage, and fortification in a variety of ways. Marine microorganisms are a possible source of novel bioactive chemicals with potential human utility. Some of these microbes can live in the harsh marine environments, resulting in complex compounds with unique biological properties that can be used in several industrial and biotechnological applications. So far, several marine microorganisms (fungi, myxomycetes, bacteria, and microalgae) have been isolated that produce antioxidant, antibacterial, apoptotic, antitumoral, and antiviral chemicals. Furthermore, it emphasizes the enormous potential for marine microbes to produce very important bioactive chemicals. They are used for new drug developments extensively across the world. Marine pharmacology offers the scope for research on these drugs of marine origin. Few institutes in India offer such opportunities which can help us in the quest for new drugs. This is an extensive review of the drugs developed and the potential new drug candidates from marine origin along with the opportunities for research on marine derived products. It also gives the information about the institutes in India which offer marine pharmacology related courses.

Keywords: Anticancer, Bryostatin, Cytarabine, Keyhole limpet hemocyanin, Mariculture, Sponge, Ziconotide

Author Biographies

Geeta Sahu, Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

Geeta Kachhi, Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

Bhupendra Thakur, Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

Anushree Jain, Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

Prateek Kumar Jain, Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

Basant Khare, Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

Adina College of Pharmacy, ADINA Campus Rd, Lahdara, Sagar, MP, 470001

References

Mora C, Tittensor DP, Adl S, Simpson AGB, Worm B. How many species are there on earth and in the ocean. PLoS Biol. 2011; 9:e1001127. https://doi.org/10.1371/journal.pbio.1001127

Leoutsakos V. A short history of the thyroid gland. Hormones.2004; 3:268-271. https://doi.org/10.14310/horm.2002.11137

Dias DA, Urban S, Roessner U. A historical overview of natural products in drug discovery. Metabolites. 2012; 2:303-336. https://doi.org/10.3390/metabo2020303

Blunt JW, Copp BR, Keyzers RA, Munro MHG, Prinsep MR. Marine natural products. Nature Product Report. 2015; 32:116-211. https://doi.org/10.1039/C4NP00144C

Torjesen I. Drug development: the journey of a medicine from lab to shelf. Pharmaceutical Journal. 2015; 926:11-21.

Glaser KB, Mayer AM. A renaissance in marine pharmacology: from preclinical curiosity to clinical reality. Biochemical Pharmacology. 2009; 78:440-448. https://doi.org/10.1016/j.bcp.2009.04.015

Rocha-Martin J, Harrington C, Dobson ADW, O'Gara F. Emerging strategies and integrated systems microbiology technologies for biodiscovery of marine bioactive compounds. Marine Drugs. 2014; 12:3516-3559. https://doi.org/10.3390/md12063516

Margulis L, Schwartz KV. Five Kingdoms- An Illustrated Guide to the Phyla of Life on Earth. 3rd ed. New York, USA: W.H. Freeman and Company; 1998.

Donia M, Hamann MT. Marine natural products and their potential applications as anti infective agents. Lancet Infect Dis. 2003; 3:338-48. https://doi.org/10.1016/S1473-3099(03)00655-8

Bergmann W, Stempien MF. Contributions to the study of marine products. XLIII. The nucleosides of sponges. V. The synthesis of spongosine. J Org Chem. 1957; 2:1557-75. https://doi.org/10.1021/jo01363a009

Murti Y, Agarwal T. Marine derived pharmaceuticals-development of natural health products from marine biodiversity. Int J ChemTech Res. 2010; 2:2198-217.

Imhoff JF, Labes A, Wiese J. Bio-mining the microbial treasures of the ocean: New natural products. Biotechnol Adv. 2011; 29:468-82. https://doi.org/10.1016/j.biotechadv.2011.03.001

Vignesh S, Raja A, James RA. Marine drugs: Implication and future studies. Int J Pharmacol. 2011; 7:22-30. https://doi.org/10.3923/ijp.2011.22.30

Anand TP, Bhat AW, Shouche YS, Roy U, Siddharth J, Sarma SP. Antimicrobial activity of marine bacteria associated with sponges from the waters off the coast of South East India. Microbiol Res. 2006; 161:252-62. https://doi.org/10.1016/j.micres.2005.09.002

Thakur NL, Thakur AN, Muller WEG. Marine natural products in drug discovery. Natural Product Radiance. 2005; 4:471-7.

Desbois AP, Mearns-Spragg A, Smith VJ. A fatty acid from the diatom Phaeodactylum tricornutum is antibacterial against diverse bacteria including multi resistant Staphylococcus aureus (MRSA). Mar Biotechnol (NY). 2009; 11:45-52. https://doi.org/10.1007/s10126-008-9118-5

Dellai A, Laroche-Clary A, Mhadhebi L, Robert J, Bouraoui A. Anti inflammatory and antiproliferative activities of crude extract and its fractions of the defensive secretion from the Mediterranean sponge. Spongia officinalis. Drug Dev Res. 2010; 71:412-8. https://doi.org/10.1002/ddr.20392

Suganthy N, Karutha Pandian S, Pandima Devi K. Neuroprotective effect of seaweeds inhabiting South Indian coastal area (Hare Island, Gulf of Mannar Marine Biosphere Reserve): Cholinesterase inhibitory effect of Hypnea valentiae and Ulva reticulata. Neurosci Lett. 2010; 468:216-9. https://doi.org/10.1016/j.neulet.2009.11.001

Ben Kahla Nakbi A, Haouas N, El Ouaer A, Guerbej H, Ben Mustapha K, Babba H. Screening of antileishmanial activity from marine sponge extracts collected off the Tunisian coast. Parasitol Res. 2010; 106:1281-6. https://doi.org/10.1007/s00436-010-1818-x

Rashid ZM, Lahaye E, Defer D, Douzenel P, Perrin B, Bourgougnon N, et al. Isolation of a sulphated polysaccharide from a recently discovered sponge species (Celtodoryx girardae) and determination of its anti herpetic activity. Int J Biol Macromol. 2009; 44:286-93. https://doi.org/10.1016/j.ijbiomac.2009.01.002

Bringmann G, Gulder TA, Lang G, Schmitt S, Stöhr R, Wiese J, et al. Large scale biotechnological production of the antileukemic marine natural product sorbicillactone A. Mar Drugs. 2007; 5:23-30. https://doi.org/10.3390/md502023

Harris JR, Markl J. Keyhole limpet hemocyanin (KLH): A biomedical review. Micron. 1999; 30:597-623. https://doi.org/10.1016/S0968-4328(99)00036-0

Curtis JE, Hersh EM, Butler WT, Rossen RD. Antigen dose in the human immune response. Dose relationships in the human immune response to Keyhole limpet hemocyanin. J Lab Clin Med. 1971; 78:61-9.

Wirguin I, Suturkova Milosevic L, Briani C, Latov N. Keyhole limpet hemocyanin contains Gal(beta 1 3) GalNAc determinants that are cross reactive with the T antigen. Cancer Immunol Immunother. 1995; 40:307-10. https://doi.org/10.1007/BF01519630

Mayer AM, Glaser KB, Cuevas C, Jacobs RS, Kem W, Little RD, et al. The odyssey of marine pharmaceuticals: A current pipeline perspective. Trends Pharmacol Sci. 2010; 31:255-65. https://doi.org/10.1016/j.tips.2010.02.005

Potts BC, Albitar MX, Anderson KC, Baritaki S, Berkers C, Bonavida B, et al. Marizomib, a proteasome inhibitor for all seasons: preclinical profile and a framework for clinical trials. Current Cancer Drug Targets. 2011; 11:254-284. https://doi.org/10.2174/156800911794519716

Newman DJ, Cragg GM. Marine-sourced anti-cancer and cancer pain control agents in clinical and late preclinical development. Marine Drugs. 2014; 12:255-278. https://doi.org/10.3390/md12010255

Lorente A, Makowski K, Albericio F, A' lvarez M. Bioactive marine polyketides as potential and promising drugs. Annals of Marine Biology and Research. 2014; 1:1003.

Rangel M, Falkenberg A. An overview of the marine natural products in clinical trials and on the market. Journal of Coastal Life Medicine. 2015; 3:421-428. https://doi.org/10.12980/JCLM.3.2015JCLM-2015-0018

Mayer AMS, Rodrıiguez AD, Taglialatela-Scafati O, Fusetani N. Marine pharmacology in 2009-2011: marine compounds with antibacterial, antidiabetic, antifungal, anti-inflammatory, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous systems, and other miscellaneous mechanisms of action. Marine Drugs. 2013; 11: 2510-2573. https://doi.org/10.3390/md11072510

Jang HJ, Nam S-J, Locke JB, Kauffman CA, Beatty DS, Paul LA, Fenical W. Anthracimycin, a potent anthrax antibiotic from a marine-derived actinomycete. Angewandte Chemie International Edition 2013; 52:7822-7824. https://doi.org/10.1002/anie.201302749

Jain M, Jain A, Khare B, Jain DK, Khan R, Jain D. An Update on the Recent Emergence of Candida auris. Asian Journal of Dental and Health Sciences. 2022; 2(1):14-9. https://doi.org/10.22270/ajdhs.v2i1.11

Jat D, Thakur N, Jain DK, Prasad S, Yadav R. Iris ensata Thunb: Review on Its Chemistry, Morphology, Ethno Medical Uses, Phytochemistry and Pharmacological Activities. Asian Journal of Dental and Health Sciences. 2022; 2(1):1-6. https://doi.org/10.22270/ajdhs.v2i1.9

Martins A, Vieira H, Gaspar H, Santos S. Marketed marine natural products in the pharmaceutical and cosmeceutical industries: Tips for success. Mar Drugs. 2014; 12:1066-101. https://doi.org/10.3390/md12021066

Molinski TF, Dalisay DS, Lievens SL, Saludes JP. Drug development from marine natural products. Nat Rev Drug Discov. 2009; 8:69-85. https://doi.org/10.1038/nrd2487

Radjasa OK, Vaske YM, Navarro G, Vervoort HC, Tenney K, Linington RG, et al. Highlights of marine invertebrate-derived biosynthetic products: Their biomedical potential and possible production by microbial associants. Bioorg Med Chem. 2011; 19:6658 74. https://doi.org/10.1016/j.bmc.2011.07.017

Maier ME. Structural revisions of natural products by total synthesis. Nat Prod Rep. 2009; 26:1105 24. https://doi.org/10.1039/b809658a

Gerwick WH, Moore BS. Lessons from the past and charting the future of marine natural products drug discovery and chemical biology. Chem Biol. 2012; 19:85 98. https://doi.org/10.1016/j.chembiol.2011.12.014

Iyer U, Kadambi VJ. Antibody drug conjugates -Trojan horses in the war on cancer. J Pharmacol Toxicol Methods. 2011; 64:207 12. https://doi.org/10.1016/j.vascn.2011.07.005

Gerwick WH, Fenner AM. Drug discovery from marine microbes. Microb Ecol. 2013; 65:800-6. https://doi.org/10.1007/s00248-012-0169-9

Khatri S, Dhanoriya C, Jain DK. Zika virus (ZIKV) disease: past, present and future. Journal of Drug Delivery and Therapeutics. 2018; 8(6-s):320-7. https://doi.org/10.22270/jddt.v8i6-s.2076

Yadav R, Jha M, Prasad S, Jat D, Jain DK. Mayaro virus (MAYV) Disease: Past, present and future. J Pharm Biol Sci. 2022; 10(1):7-16.

Khatri S, Jain DK. Autism spectrum disorder (ASD): past, present and future. CIBTech Journal of Pharmaceutical Sciences. 2018; 7(4):1-25.

Published

15-09-2022

How to Cite

Sahu, G., Kachhi, G. ., Thakur, B., Jain, A., Jain, P. K. ., & Khare, B. (2022). Novel Bioactive Compounds from Marine Sources as a Tool for Drug Development. International Journal of Medical Sciences and Pharma Research, 8(3), 33–38. https://doi.org/10.22270/ijmspr.v8i3.57

Most read articles by the same author(s)