Synthesis, Characterization and Anti-Convulsant Activity of Novel Substituted Oxadiazole Derivatives
DOI:
https://doi.org/10.22270/ijmspr.v8i2.39Keywords:
Selected:Oxadiazole, Oxadiazole derivatives, Convulsion, Anti-convulsant activityAbstract
Seizures are sudden, transitory, and uncontrolled episodes of brain dysfunction resulting from abnormal discharge of neuronal cells with associated motor, sensory or behavioral changes. Anticonvulsants (also commonly known as antiepileptic drugs or as ant seizure drugs) are a diverse group of pharmaceuticals used in the treatment of epileptic seizures. Anticonvulsants are also increasingly being used in the treatment of bipolar disorder, since many seem to act as mood stabilizers, and for the treatment of neuropathic pain. Anticonvulsants suppress the rapid and excessive firing of neurons during seizures. Anticonvulsants also prevent the spread of the seizure within the brain. Synthesis of starting material by reacting with KOH resulting substituted benzoate obtained then (2.58gm, 10 m mol) DMF (10 ml), hydrazine hydrate (50 m mol) was added give substituted hydrazide product then take methanolic solution of hydrazide product (5.1 m mol), cyanogens bromide (7.5 m mol) was added give oxadiazole derivatives, The purity of all compounds have been checked by the TLC monitoring and the conformation of structure will be checked by different spectra like IR, Mass and NMR, and then evaluated for anti-convulsant activity.
Keywords: Oxadiazole, Oxadiazole derivatives, Convulsion, Anti-convulsant activity.
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