Synthesis, Characterization and Anti-Diabetic Activity of Novel 2-Substituted Indole Derivatives
DOI:
https://doi.org/10.22270/ijmspr.v8i2.36Keywords:
2-Phenylindole, Carbazole, Diabetes, Anti-diabetic activity, IndoleAbstract
Accordingly, the nitrogen in each nucleus, viz. 2-phenylindole, carbazole, phenothiazine and dibenzylamine, was planned to be alkylated applying several N-alkylating conditions, using either bromochloropropane or bromochlorobutane to give alkylated products with chloro-group available at the end of 2-carbon and 3-carbon chain. The chloro-group can then thought be utilized in reaction with p-hydroxyacetophenone to form ethereal linkage, by applying conditions of Williamson’s ether synthesis. The acetyl group present in the products could then easily be converted into indole ring using conditions of Fischer’s-indole synthesis.57 Further, it was planned to confirm the structures of synthesized compounds using spectral and elemental analysis, apart from simple laboratory techniques like physical constants and classical chemical tests.
Keywords: Indole, 2-Phenylindole, Carbazole, Diabetes, Anti-diabetic activity.
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