DEVELOPMENT & EVALUATION OF FAST DISINTEGRATING FILMS AND TABLETS OF VALSARTAN

G  Sandhyarani; M  Madhuri

doi:10.22270/ijmspr.v4i1.23

Authors

G Sandhyarani Vaageswari College of Pharmacy, Karimnager, India
M Madhuri Vaageswari College of Pharmacy, Karimnager, India

DOI:

https://doi.org/10.22270/ijmspr.v4i1.23

Keywords:

Valsartan, Disintegrating films, Tablets, Valsartan, Disintegrating films, Tablets

Abstract

Orodispersible dosage forms are used for accurate dosing, enhanced bioavailability, rapid action, patient compliance, easy of administration, enhanced palatability. Valsartan is a specific and selective type-1 angiotensin II receptor antagonist which blocks the blood pressure increasing effects angiotensin II via the renin-angiotensin-aldosterone system. Valsaratan orodispersible films are prepared using all polymers HPMC E3,HPMC E15,HPMC 5cps,HPMC 15cps,HPMC 50cps, HPMC 50cps+CP in 39.68 mg., 59.52 mg quantity with different formulations with citric acid as disintegrating agent. Valsartan orodispersible tablets are prepared using different superdisintegrating agents(MCC pH101,MCC pH102, CCS, SSG, L-HPC, Crospovidone, Camphor) with different concentrations. ODF formulation F1, F5 exhibited faster disintegration time (11 sec, 13 sec) than other formulations and a drug release of 102.12%, 98.27% respectively. ODT formulations(CP+CCS), T9(efferevescence), T10(sublimation) showed faster disintegration (17,21,18 sec) and 94.18%, 92.62%, 93.54% drug release at the end of 15 minutes. By comparing the drug release studies found that ODFs drug release more than ODTs.

Author Biographies

G Sandhyarani, Vaageswari College of Pharmacy, Karimnager, India

Vaageswari College of Pharmacy, Karimnager, India

M Madhuri, Vaageswari College of Pharmacy, Karimnager, India

Vaageswari College of Pharmacy, Karimnager, India

References

Arya A, Chandra A, Sharma V, Pathak K (2010), “Fast Dissolving Oral Films: An Innovative Drug Delivery System and Dosage Form”, Int J ChemTech Res., Vol. 2, pp. 576-583.

Choudhary D R, Patel V A , kundawala A J (2011), “Formulation and Evaluation of Quick Dissolving Film of Levocetirizine Dihydrochloride”, Int J Pharma Tech., Vol. 3, No. 1, pp. 1740-1749.

Dixit R P and Puthli S P (2009), “Oral Strip Technology: Overview and Future Potential”, J of Cont Release, Vol. 139, pp. 94-107.

Jain C P and Naruka P S (2009), Formulation and Evaluation of Fast Dissolving Tablets of Valsartan”, International Journal of Pharmaceutical Sciences, Vol. 1, No. 1, July-September.

Kunte S and Tandale P (2010), “Fast Dissolving strips: A novel Approach for the Delivery of Verapamil”, J Pharm Bioallied Sci., Oct-Dec; Vol. 2, No. 4, pp. 325-328.

Mishra R and Amin A (2011), “Formulation and Characterization of Rapidly Dissolving Films of Cetirizine hydrochloride using Pullulan as a Film Forming Agent”, Ind J Pharm Edu Res, Vol. 45, No. 1, pp. 75-76.

Patil S B and Shahi S R (2009), “Formulation and Evaluation of Quick Dispersible Tablet of Olanzapine”, Int J Pharma Res Dev, Vol. 7, pp. 30-34.

Raju S, Reddy P and Kumar V (2011), “Flash Release Oral Films of Metoclopramide Hydrochloride For Pediatric Use: Formulation And In-vitro Evaluation, J. Chem Pharm Res., Vol. 3, No. 4, pp. 636- 646.

Saini S, Nanda A and Dhari J (2011), “Formulation, Development & Evaluation of Oral Fast Dissolving Anti-allergic film of Levocetrizine Dihydrochloride”, J Pharm Sci & Res., Vol. 3, No. 7, pp. 1322-1325