EFFECT OF BAUHINIA VARIEGATA STEM BARK AQUEOUS EXTRACT ON HYPERGLYCEMIA, NEUROPATHY AND DIABETIC COMPLICATIONS IN STREPTOZOTOCIN INDUCED DIABETIC RATS
DOI:
https://doi.org/10.22270/ijmspr.v4i1.22Keywords:
Bauhinia variegata, Diabetes, Neuropathy, Hyperglycemia, StreptozotocinAbstract
Protective activity of Bauhinia variegata aqueous extract in diabetic complication on streptozotocin (STZ)-induced diabetic rats was done using Male Wistar albino rats (150–200 g) by single intraperitoneal injection of STZ (65 mg/kg b.w i. p). Rats (n = 24) were divided into four groups of six animals each. Group 1 (normal control) and Group 2 (diabetic control) received normal saline (10 ml/kg/day p. o). Group 3 (Standard, insulin 6 U/kg/day s. c) and Group 4 (received Bauhinia variegata aqueous extract in dose of 1000 mg/ kg) for 28 days. Bauhinia variegata group animals exhibited substantial decrease in blood glucose, SGOT, SGPT, creatinine, urea, triglycerides, LDL and glycated hemoglobin. It particularly had protective effect in diabetic complications like neuropathy and learning and memory dysfunction evaluated by elevated plus maze, object recognition, open field test, rotarod, hot plate, tail flick, immersion in hot and cold water etc. Hence it can be concluded that Bauhinia variegata aqueous extract has potential antidiabetic and protective activity in diabetic complications in STZ-induced diabetic rats and can be considered as an alternative in Diabetes management therapy.
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