Oxidative Stress and Pregnancy-induced Hypertension: Antioxidant Solutions
DOI:
https://doi.org/10.22270/ijmspr.v10i4.119Keywords:
oxidative stress, pregnancy-induced hypertension, antioxidants, endothelial dysfunction, maternal healthAbstract
Pregnancy-induced hypertension (PIH) is a significant complication of pregnancy, contributing to adverse maternal and fetal outcomes. Recent research has illuminated the role of oxidative stress in the pathogenesis of PIH, characterized by an imbalance between reactive oxygen species (ROS) production and antioxidant defenses. This review examines the mechanisms by which oxidative stress contributes to endothelial dysfunction, increased vascular resistance, and systemic inflammation in the context of PIH. By elucidating these mechanisms, the review highlights the critical need for effective strategies to mitigate oxidative stress during pregnancy. Antioxidants have emerged as potential therapeutic agents for managing oxidative stress and preventing PIH. Various antioxidants, including vitamins C and E, omega-3 fatty acids, and coenzyme Q10, have shown p.romise in reducing oxidative damage and improving vascular health during pregnancy. Clinical trials have suggested that supplementation with these antioxidants may enhance endothelial function and lower blood pressure in at-risk pregnant women, thereby decreasing the incidence of PIH and related complications.
Keywords: oxidative stress, pregnancy-induced hypertension, antioxidants, endothelial dysfunction, maternal health
References
Okamgba OC, Nwosu DC, Nwobodo EI, Agu GC, Ozims SJ, Obeagu EI, Ibanga IE, Obioma-Elemba IE, Ihekaire DE, Obasi CC, Amah HC. Iron Status of Pregnant and Post-Partum Women with Malaria Parasitaemia in Aba Abia State, Nigeria. Annals of Clinical and Laboratory Research. 2017;5(4):206.
Agreen FC, Obeagu EI. Anaemia among pregnant women: A review of African pregnant teenagers. Journal of Public Health and Nutrition. 2023;6(1):138.
Obeagu EI, Obeagu GU. Eosinophil Dynamics in Pregnancy among Women Living with HIV: A Comprehensive Review. Int. J. Curr. Res. Med. Sci. 2024;10(1):11-24. https://doi.org/10.22270/ijmspr.v10i2.95
Obeagu EI, Obeagu GU, Chukwueze CM, Ikpenwa JN, Ramos GF. Evaluation of protein C, protein S and fibrinogen of pregnant women with malaria in Owerri metropolis. Madonna University journal of Medicine and Health Sciences ISSN: 2814-3035. 2022 Apr 19;2(2):1-9.
Obeagu EI, Obeagu GU. Eosinophilic Changes in Placental Tissues of HIV-Positive Pregnant Women: A Review. Elite Journal of Laboratory Medicine, 2024; 2(1): 14-32
Joo EH, Kim YR, Kim N, Jung JE, Han SH, Cho HY. Effect of endogenic and exogenic oxidative stress triggers on adverse pregnancy outcomes: preeclampsia, fetal growth restriction, gestational diabetes mellitus and preterm birth. International journal of molecular sciences. 2021;22(18):10122. https://doi.org/10.3390/ijms221810122
Juan CA, Pérez de la Lastra JM, Plou FJ, Pérez-Lebeña E. The chemistry of reactive oxygen species (ROS) revisited: outlining their role in biological macromolecules (DNA, lipids and proteins) and induced pathologies. International journal of molecular sciences. 2021;22(9):4642. https://doi.org/10.3390/ijms22094642
Feng Y, Feng Q, Qu H, Song X, Hu J, Xu X, Zhang L, Yin S. Stress adaptation is associated with insulin resistance in women with gestational diabetes mellitus. Nutrition & diabetes. 2020;10(1):4. https://doi.org/10.1038/s41387-020-0107-8
Obeagu EI, Abdirahman BF, Bunu UO, Obeagu GU. Obsterics characteristics that effect the newborn outcomes. Int. J. Adv. Res. Biol. Sci. 2023;10(3):134-43.
Anyiam AF, Obeagu EI, Obi E, Omosigho PO, Irondi EA, Arinze-Anyiam OC, Asiyah MK. ABO blood groups and gestational diabetes among pregnant women attending University of Ilorin Teaching Hospital, Kwara State, Nigeria. International Journal of Research and Reports in Hematology. 2022;5(2):113-121.
Okorie HM, Obeagu EI, Eze EN, Jeremiah ZA. Assessment of some haematological parameters in malaria infected pregnant women in Imo state Nigeria. Int. J. Curr. Res. Biol. Med. 2018;3(9):1-4.
Okorie HM, Obeagu EI, Eze EN, Jeremiah ZA. Assessment of coagulation parameters in malaria infected pregnant women in Imo state, Nigeria. International Journal of Current Research in Medical Sciences. 2018;4(9):41-9.
Obeagu EI, Obeagu GU. Neonatal Outcomes in Children Born to Mothers with Severe Malaria, HIV, and Transfusion History: A Review. Elite Journal of Nursing and Health Science, 2024; 2(3): 38-58
Obeagu EI, Obeagu GU. The Vital Role of Antioxidants in Enhancing Fertility and Pregnancy Success: A Review. Elite Journal of Nursing and Health Science. 2023;1(1):1-2.
Obeagu EI, Ubosi NI, Uzoma G. Antioxidant Supplementation in Pregnancy: Effects on Maternal and Infant Health. Int. J. Adv. Multidiscip. Res. 2023;10(11):60-70.
Obeagu EI, Obeagu GU. Enhancing Maternal and Fetal Well-being: The Role of Antioxidants in Pregnancy. Elite Journal of Medical Sciences. 2024;2(4):76-87.
Obeagu EI, Obeagu GU. Harnessing the Power of Antioxidant-Rich Diet for Preconception Health: A Review. Elite Journal of Health Science. 2023;1(1):1-3.
Nowak D, Gośliński M, Wojtowicz E, Przygoński K. Antioxidant properties and phenolic compounds of vitamin C‐rich juices. Journal of Food Science. 2018;83(8):2237-2246. https://doi.org/10.1111/1750-3841.14284
Obeagu EI, Adias TC, Obeagu GU. Influence of Antioxidants on Maternal and Fetal Immune Response: A Review. Elite Journal of Nursing and Health Science. 2024;2(6):1-3.
Obeagu EI, Batisani K, Obeagu GU. Antioxidants and Neurodevelopmental Outcomes in Offspring: A Review of Maternal Interventions. Elite Journal of Health Science. 2023;2(5):1-9.
Obeagu EI, Batisani K, Obeagu GU. Antioxidants and Postpartum Complications: Preventions. Elite Journal of Nursing and Health Science. 2024;2(5):30-40.
Obeagu EI, Obeagu GU. Antioxidants and Gestational Diabetes Mellitus: A Comprehensive Review of Preventive Strategies. Elite Journal of Health Science. 2024;2(5):19-29.
Obeagu EI, Obeagu GU. Harnessing the Power of Antioxidants: Enhancing Gamete Quality and Fostering Successful Pregnancy. Elite Journal of Nursing and Health Science. 2024;2(3):73-83.
Obeagu EI, Muhimbura E, Obeagu GU. Hypoxia-Induced Oxidative Stress: Maternal and Fetal Implications. Elite Journal of Haematology, 2024; 2 (8).:57-72.
Obeagu EI, Obeagu GU. Managing Hypoxia in Pregnancy: Current Strategies and Future Directions. Elite Journal of Medical Sciences. 2024;2(8):53-63.
Obeagu EI, Obeagu GU. Hypoxia-induced Metabolic Changes in Pregnancy: Clinical Perspectives. Elite Journal of Medicine. 2024;2(8):50-9.
Obeagu EI, Chukwu PH. Maternal Well-being in the Face of Hypoxia during Pregnancy: A Review. Int. J. Curr. Res. Chem. Pharm. Sci. 2024;11(7):25-38.
Dhakar RC, Prajapati SK, Maurya SD, Tilak VK, Das MK, Das S, Verma KK, Jain N, Antioxidant Potential of Cordia dichotoma: A Review, Asian Journal of Dental and Health Sciences. 2021;1(1):19-23https://doi.org/10.22270/ajdhs.v1i1.6
Obeagu EI, Obeagu GU. Oxygen Deprivation in Pregnancy: Understanding Hypoxia's Impact on Maternal Health. Journal home page: http://www. journalijiar. com.;12(01).
Obeagu EI, Obeagu GU. Hypoxia-Induced Inflammation: Implications for Maternal Health. Elite Journal of Scientific Research and Review. 2024;2(6):8-25.
Obeagu EI, Obeagu GU. Hypoxia in Pregnancy: Implications for Fetal Development. Int. J. Curr. Res. Chem. Pharm. Sci. 2024;11(7):39-50.
Obeagu EI, Obeagu GU. Hypoxia and Pregnancy: The Role of Genetics and Epigenetics. Elite Journal of Medical Sciences. 2024;2(8):24-36.
Carter AM. Evolution of placental function in mammals: the molecular basis of gas and nutrient transfer, hormone secretion, and immune responses. Physiological reviews. 2012;92(4):1543-1576. https://doi.org/10.1152/physrev.00040.2011
Obeagu EI, Obeagu GU. Maternal Hypoxia: Impact on Immune System Development in Offspring. Elite Journal of Health Science. 2024;2(8):45-57.
Obeagu EI, Obeagu GU. Maternal Hypoxia and Placental Dysfunction: Insights from Molecular Biology. Elite Journal of Health Science. 2024;2(8):58-69.
Kalagiri RR, Carder T, Choudhury S, Vora N, Ballard AR, Govande V, Drever N, Beeram MR, Uddin MN. Inflammation in complicated pregnancy and its outcome. American journal of perinatology. 2016;33(14):1337-1356. https://doi.org/10.1055/s-0036-1582397
Al-Gubory KH. Environmental pollutants and lifestyle factors induce oxidative stress and poor prenatal development. Reproductive biomedicine online. 2014;29(1):17-31. https://doi.org/10.1016/j.rbmo.2014.03.002
Boeldt DS, Bird IM. Vascular adaptation in pregnancy and endothelial dysfunction in preeclampsia. The Journal of endocrinology. 2017;232(1):R27. https://doi.org/10.1530/JOE-16-0340
Burton GJ, Cindrova-Davies T, wa Yung H, Jauniaux E. Hypoxia and reproductive health: Oxygen and development of the human placenta. Reproduction. 2021;161(1):F53-65. https://doi.org/10.1530/REP-20-0153
He L, He T, Farrar S, Ji L, Liu T, Ma X. Antioxidants maintain cellular redox homeostasis by elimination of reactive oxygen species. Cellular Physiology and Biochemistry. 2017;44(2):532-553. https://doi.org/10.1159/000485089
Ighodaro OM, Akinloye OA. First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid. Alexandria journal of medicine. 2018;54(4):287-293. https://doi.org/10.1016/j.ajme.2017.09.001
Roy Z, Bansal R, Siddiqui L, Chaudhary N. Understanding the role of free radicals and antioxidant enzymes in human diseases. Current Pharmaceutical Biotechnology. 2023;24(10):1265-1276. https://doi.org/10.2174/1389201024666221121160822
Mirończuk-Chodakowska I, Witkowska AM, Zujko ME. Endogenous non-enzymatic antioxidants in the human body. Advances in medical sciences. 2018;63(1):68-78. https://doi.org/10.1016/j.advms.2017.05.005
Sebastiani G, Navarro-Tapia E, Almeida-Toledano L, Serra-Delgado M, Paltrinieri AL, García-Algar Ó, Andreu-Fernández V. Effects of antioxidant intake on fetal development and maternal/neonatal health during pregnancy. Antioxidants. 2022;11(4):648. https://doi.org/10.3390/antiox11040648
Rumbold AR, Crowther CA, Haslam RR, Dekker GA, Robinson JS. Vitamins C and E and the risks of preeclampsia and perinatal complications. New England Journal of Medicine. 2006;354(17):1796-1806. https://doi.org/10.1056/NEJMoa054186
Cederberg J, Simán CM, Eriksson UJ. Combined treatment with vitamin E and vitamin C decreases oxidative stress and improves fetal outcome in experimental diabetic pregnancy. Pediatric research. 2001;49(6):755-762. https://doi.org/10.1203/00006450-200106000-00007
Perkins AV. Placental oxidative stress, selenium and preeclampsia. Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health. 2011;1(1):95-99. https://doi.org/10.1016/j.preghy.2010.10.008
Rayman MP, Searle E, Kelly L, Johnsen S, Bodman-Smith K, Bath SC, Mao J, Redman CW. Effect of selenium on markers of risk of pre-eclampsia in UK pregnant women: a randomised, controlled pilot trial. British Journal of Nutrition. 2014;112(1):99-111. https://doi.org/10.1017/S0007114514000531
Luo J, Wu W, Zhang P, Chen X, Feng Y, Ma N, Yang H, Wang Y, Li M, Xie B, Guo P. Zinc levels and birth weight in pregnant women with gestational diabetes mellitus: a matched cohort study in China. The Journal of Clinical Endocrinology & Metabolism. 2020;105(7): e2337-2345. https://doi.org/10.1210/clinem/dgaa171
Sley EG, Rosen EM, van 't Erve TJ, Sathyanarayana S, Barrett ES, Nguyen RH, Bush NR, Milne GL, Swan SH, Ferguson KK. Omega-3 fatty acid supplement use and oxidative stress levels in pregnancy. PloS one. 2020;15(10): e0240244. https://doi.org/10.1371/journal.pone.0240244
Orhan H, Önderoglu L, Yücel A, Sahin G. Circulating biomarkers of oxidative stress in complicated pregnancies. Archives of gynecology and obstetrics. 2003; 267:189-195. https://doi.org/10.1007/s00404-002-0319-2
Barbosa ML, de Meneses AA, de Aguiar RP, e Sousa JM, Cavalcante AA, Maluf SW. Oxidative stress, antioxidant defense and depressive disorders: a systematic review of biochemical and molecular markers. Neurology, Psychiatry and Brain Research. 2020; 36:65-72. https://doi.org/10.1016/j.npbr.2020.02.006
Di Fabrizio C, Giorgione V, Khalil A, Murdoch CE. Antioxidants in pregnancy: do we really need more trials? Antioxidants. 2022 Apr 22;11(5):812. https://doi.org/10.3390/antiox11050812
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