A CLINICAL STUDY TO ASSESS THE EFFECT OF PROPHYLACTIC INTRACAMERAL MOXIFLOXACIN ON INCIDENCE OF ENDOPHTHALMITIS IN HIGH VOLUME SURGERY SETUP
DOI:
https://doi.org/10.22270/ijmspr.v1i4.11Keywords:
Endophthalmitis, Intracameral, Moxifloxacin, ProphylacticAbstract
Endophthalmitis is still the major post operative complication of ocular surgery. Most common
cause for endophthalmitis to develop after ocular surgery is the inhabitant microbial flora of
conjunctiva and periocular tissue. This study was conducted with the aim to assess the effect
of prophylactic intracameral moxifloacin on incidence of endophthalmitis in high volume surgery
setup. Patient were divided into two groups, group 1 which didn’t received intracameral
moxifloxacin at the end of surgery and group 2 which received prophylactic intracameral
moxifloxacin at the end of surgery. We have achieved zero incidences of endophthalmitis with
intracameral moxifloxacin. Our findings consolidate the view that use of intracameral antibiotics
decreases the rate of enopthalmitis.
References
Teban M. Behrane S, Newcomb et al. (2005), “Acute endophthalmitis following cataract surgery: A systemic review of literature”, Arch ophthal., Vol. 123, pp. 613 - 6204.
West E S, Behrens A, McDonnell PJ, et al. (2005), “The incidence of endophthalmitis after cataract surgery among the U.S. Medicare population between 1994 and 2001”, Ophthalmology, Vol. 112, pp. 1388- 94.
Jonson M W, Doft B H, Kelsey S F (1997), “The Endophthalmitis Vitrectomy study; relationship between clinical presentation and microbiologic spectrum; The endophthalmitis Study Group”, Ophthalmology, Vol. 104, pp. 261-72.
Walker C B and Claoue C M (1986), “Incidence of conjunctival colonization by bacteria capable of causing postoperative endophthalmitis”, J R Soc Med., Vol. 79, pp. 520-21.
Srinivasan R, Reddy R A, Rene S, et al. (1999), “Bacterial contamination of anterior chamber during IOL surgery”, IJO , Vol. 47, pp. 185-9.
Ciulla T A, Starr M B, Masket S (2002), “Bacterial endophthalmitis prophylaxis for cataract surgery; an evidence based update”, Ophthalmology, Vol. 109, pp. 13- 24.
Isenberg S J, Apt L, Yoshimoro R (1997), “Efficacy of topical povidoneiodine during the first week after ophthalmic surgery”, Am J Ophthalmol., Vol. 124, pp. 31-5.
Seal D V, Barry P, Gettinby G, et al. (2006), “ESCRS study of prophylaxis of postoperative endophthalmitis after cataractsurgery: case for a European multicenter study; the ESCRS Endophthalmitis Study Group”, J Cataract Refract Surg., Vol. 32, pp. 396-406.
ESCRS (2007), “Endophthalmitis study group ,Prophylaxis of postoperative endophthalmitis following cataract surgery: results of theESCRS multicenter study and identification of risk factors”, J Cataract Refract Surg., Vol. 33, pp. 978–988
Montan P G, Wejde G, Setterquist H, et al. (2002), “Prophylactic intracameral cefuroxime; evaluation of safety and kinetics in cataractsurgery”, J Cataract Refract Surg., Vol. 28, pp. 982–987
Han D P, Wisniewski S R, Wilson L A, et al. (1996), “Spectrum and susceptibilities of microbiologic isolates in the Endophthalmitis VitrectomyStudy; the Endophthalmitis Vitrectomy Study Group”, Am J Ophthalmol., Vol. 122, pp. 1–17.
Leaming D V (2004), “Practice styles and preferences of ASCRS members- 2003 survey”, J Cataract Refract Surg., Vol. 30, pp. 892-900.
Gimbel H V and Sun R (2000), “Prophylactic intracameral vancomycin and CME [letter]”, Ophthalmology , Vol. 107, pp. 1614–1615.
Axer-Siegel R, Stiebel-Kalish H, Rosenblatt I, et al. (1999), “Cystoid macular edema after cataract surgery with intraocular vancomycin”, Ophthalmology, Vol. 106, pp. 1660–1664
Kowalski R P, Romanowski E G, Mah F S, et al. (2005), “Intracameral Vigamox (moxifloxacin 0.5%) is non-toxic and effective in preventing endophthalmitisin a rabbit model”, Am J Ophthalmol., Vol. 140, pp. 497–504.
Stroman D W, Dajcs J J, Cupp G A, Schlech B A (2005), “In vitro and in vivo potency of moxifloxacin and moxifloxacin ophthalmic solution 0.5%; a new topical fluoroquinolone”, Surv Ophthalmol ., Vol. 50(suppl), pp. S16– S31.
Espiritu C R G, Caparas V L, Bolinao J G (2007), “Safety of intracameral Moxifloxacin 0.5% ophthalmic solution in cataract surgery patients”, J Cataract Refract Surg., Vol. 33: pp. 63-8.
Obrien O T, Arshinoff S, Mah F (2007), “Perspectives on antibiotics for postoperative endophthalmitis prophylaxis: potential role of Moxifloxacin”, J Cataract Refract Surg., Vol. 33, pp. 1790-180.
Ravilla D Ravindran, Rengraj Venkatesh, David F Chang (2009), “Incidence of endophthalmitis in post cataract surgery in arvind eye hospital”, J Cataract Refract Surg., Vol. 35, pp. 629-636
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Copyright (c) 2015 Pooja Shukla, Rahul Kumar, Ravi Tripathi, Ravi Chandil, R K Dixit
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