Factors Affecting the Stability of Probiotics in Pharmaceutical Products: A Comprehensive Review
DOI:
https://doi.org/10.22270/ijmspr.v12i3.195Keywords:
Probiotics in Pharmaceutical Products, The stability of probiotics in pharmaceutical products, factors affecting probiotics products stabilityAbstract
Stability of probiotics in pharmaceutical formulations is an important factor in determining the efficacy, product quality and regulatory requirements. In pharmaceuticals, probiotics are now being included to improve gastrointestinal immunity, gastrointestinal health, and to prevent or treat a number of diseases. But, survival and activity of probiotics during processing, storage and shelf life is still a challenge. Various factors which affect probiotic stability are strain selection, formulation type, excipients, moisture content, exposure to oxygen, temperature, packaging materials and storage conditions. Moreover, if the processing conditions are not optimized, such as drying, encapsulation and compression, the survival of probiotics may be negatively impacted. This thorough review critically analyzes the most important physicochemical, technological and environmental parameters that impact the stability of probiotics in pharmaceutical formulations. The main strategies used to improve the stability of probiotics, such as microencapsulation, protective carriers, packaging and controlled storage conditions are presented. In addition, regulatory issues and quality control strategies concerning the stability testing of probiotics and label claims are emphasized. To ensure the development of stable, effective and high-quality probiotic pharmaceutical products with consistent probiotic health promoting benefits for consumers, particular emphasis is put on understanding and control of these factors
Keywords: Probiotics in Pharmaceutical Products, the stability of probiotics in pharmaceutical products, factors affecting probiotics products stability.
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